"Baking Soda (Sodium Bicarbonate) isina chepfu uye isingakuvadzi yakavharirwa mu "capsule" yakachengeteka (liposome), uye tetracycline ine simba rekubatanidza mapfupa inoiswa pamusoro kuti isvike pamusoro pemapfupa. Kana maosteoclast achiparadza tishu dzemapfupa nekuburitsa acid, anogona kuburitsa Sodium Bicarbonate nekukasika, zvichidzivisa kushanda kwemaosteoclasts uye kuzadzisa chinangwa chekudzivirira osteoporosis zvakanyanya." Chikwata chinotungamirwa naProfessor Shunwu Fan weDhipatimendi reMaorthopedics, Run Run Shaw Hospital, Zhejiang University, naProfessor Ruikang Tang weDhipatimendi reChemistry, Zhejiang University, munguva pfupi yapfuura vakaburitsa zvavakawana muJournal of the American Chemical Society.
Sekutaura kwekutanga, maosteoclast akafanana nemagwenzi ari mumuti, aimboshanda, kunyange muti murefu, asiwo nekuda kwekuora kwenguva refu nekudonha. Zvidzidzo zvemazuva ano zvinotenda kuti chikonzero chikuru cheosteoporosis kushanda zvisina kujairika kwemaosteoclast, uye kuburitswa kweasidhi nemaosteoclast kunoonekwa sechikonzero chikuru chekutanga kwekuparadzwa kwemapfupa nemaosteoclast uye chinhu chinodiwa kuti mapfupa awo aputsike.
Mishonga mikuru mukurapa osteoporosis inozadzisa chinangwa chekudzivirira kusvetwa kwemapfupa uye kukurudzira anabolism yemapfupa nekutarisa pakugadzirisa osteoclast kana osteoblast biology, asi haiuraye danho rekutanga rekutanga kwekunze kweacid yekuumbwa kweosteoclast kubva panobva. Nokudaro, mishonga iripo inogona kunonoka kurasikirwa nemapfupa kune vakwegura kusvika pamwero wakati, asi kazhinji haigone kudzoreredza zvachose kuparadzwa kwemapfupa kwakaitika, uye kusarudzwa kwemishonga isiri yemapfupa kunogonawo kutungamira kune zvimwe migumisiro ine chepfu yenhengo dzemuviri.
Pamusoro pezvo, kunyange hazvo maosteoclast ari iwo anokonzera osteoporosis, zvidzidzo zvakawanda zvakaratidza kuti anoita basa guru mukusimudzira kuumbwa kwemapfupa uye angiogenesis se "masero anotangira" asati aburitsa acid. Saka, zvakakosha zvikuru kudzivirira maosteoclast nemazvo.
Chikwata chaFan Shunwu nechikwata chaTang Ruikang ndivo vakatanga kutarisisa Sodium Bicarbonate liposomes pamusoro pemapfupa, vachigadzira alkaline protective layer, vachideredza acid inoburitswa nemaosteoclasts, vachidzivisa kushanda kwemaosteoclasts zvisina kujairika, uye vachichinja kuenzana kwenzvimbo yemapfupa kuti vawane mhedzisiro yekurapa osteoporosis.
Lin Xianfeng, chiremba wemapfupa paRun Run Shaw Hospital yeZhejiang University, akati ongororo iyi yakawana kuti zvinhu zvine alkaline liposome pamwe nenzvimbo ine acidic ye osteoclasts zvakakonzera apoptosis yakawanda ye osteoclasts, uye zvakaburitsawo huwandu hwakawanda hwe extracellular vesicles. "Zvakafanana neseti yema dominoes, ayo anosundwa danho rimwe panguva uye anokudzwa nhanho imwe neimwe kuti adzivise kuparadzwa kwemapfupa kunokonzerwa nekusimba kwe osteoclasts."
Nguva yekutumira: Ndira-27-2021