"Iyo isina-chepfu uye isina njodzi Baking Soda (Sodium Bicarbonate) yakavharirwa mune yakachengeteka nano 'kapsule' (liposome), uye tetracycline ine simba-rinosunga pfupa rakaiswa pamusoro pevhu kushambadza kune iro bhonzo pamusoro. Kana maosteoclasts achiparadza bone nekuvhara asidi, vanogona kubva vangoburitsa Sodium Bicarbonate, ichivhiringidza mashandiro emaosteoclasts uye kuzadzisa chinangwa chekudzivirira osteoporosis zvakanyanya. ” Chikwata chakatungamirwa naPurofesa Shunwu Fan weDhipatimendi reOrthopedics, Run Run Shaw Hospital, Zhejiang University, uye Muzvinafundo Ruikang Tang weDhipatimendi reKemistry, Zhejiang University, vachangobva kuburitsa zvavakawana muJenali yeAmerican Chemical Society.
Sekureva kwesumo, maosteoclast akafanana nemujuru mumuti, wakamboshanda, kunyangwe muti wakareba, asiwo nekuda kwekuora kwenguva refu uye kudonha. Ongororo dzazvino dzinotenda kuti chikuru chinokonzeresa osteoporosis kusanzwisisika mashandiro eosteoclasts, uye asidhi yakavharirwa nemaosteoclast inoonekwa sechinhu chikuru chekutanga chekuparadza kwemapfupa nemaosteoclast uye chinodiwa chinodiwa pakukanganisa kwavo kwemapfupa.
Mishonga mikuru yekurapwa kwe osteoporosis inozadzisa chinangwa che anti-bone resorption uye kusimudzira mapfupa anabolism nekutarisa pane mutemo we osteoclast kana osteoblast biology, asi havauraye nhanho yekutanga kiyi yekunze asidi nharaunda yeosteoclast maitiro kubva ku mabviro. Naizvozvo, mishonga iripo inogona kudzora kurasikirwa kwefupa kune vakwegura kusvika pamwero wakati, asi kazhinji haigone kudzoreredza kuparadzwa kwemapfupa kwakaitika, uye kusarudzika kwekutonga kwemishonga isiri yemapfupa kunogona zvakare kutungamira kune kwakanangwa uye zvimwe zvinokanganisa mitezo yemitezo.
Mukuwedzera, kunyange zvazvo osteoclasts ndiyo inokonzera osteoporosis, zvidzidzo zvakawanda zvakaratidza kuti vanoita basa mukusimudzira kuumbwa kwemapfupa uye angiogenesis se "precursor cells" vasati vadzivirira asidi. Naizvozvo, zvakakosha kwazvo kunyatsodzivisa maosteoclast.
Chikwata chaFan Shunwu nechikwata chaTang Ruikang chakapayona kutariswa kweSodium Bicarbonate liposomes kusvika kumusoro kwepfupa, ichigadzira dziviriro yealkaline, kutapudza asidhi yakavharirwa nemaosteoclast, kudzivisa kumisikidza kushomeka kwemaosteoclast, uye kuumbazve muyero wemapfupa microenvelo kuti ikwanise kuita kurapa osteoporosis .
Lin Xianfeng, chiremba wemapfupa paRun Run Shaw Chipatara cheZhejiang University, akati chidzidzo ichi chakawana kuti alkaline liposome zvishandiso uye nharaunda acidic nharaunda yemaosteoclast yakakonzera huwandu hukuru hweapoptosis yeosteoclasts, uyezve yakaburitsa huwandu hukuru hwemasero ekunze. "Rakaita seti yemadzishe, ayo anosundirwa nhurikidzwa imwe panguva uye anokwidziridzwa nhanho imwe panguva yekumira zvakazara kuparara kwemapfupa kunokonzerwa nekusimbiswa kwemaosteoclast."
Post nguva: Jan-27-2021